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Preparation of carbon‐14 and tritium labeled d ‐ and l ‐1, 1‐diphenyl‐2‐methyl‐3‐ aminopropanol hydrochloride
Author(s) -
Thomas Richard C.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150171
Subject(s) - chemistry , tritium , yield (engineering) , hydrochloride , carbon fibers , lithium (medication) , radiochemistry , carbon 14 , medicinal chemistry , nuclear chemistry , organic chemistry , metallurgy , medicine , materials science , physics , quantum mechanics , composite number , nuclear physics , composite material , endocrinology
Abstract 1, 1‐Diphenyl‐2‐methyl‐3‐aminopropanol‐1‐ 14 C was prepared in a five‐step sequence of reactions from 14 (CO 2 and resolved into its d and l isomers in an overall yield of 9.5% based on carbon‐14. 1,1‐Diphenyl‐2‐methyl‐3‐aminopropanol‐3‐ 3 H was prepared by reduction of an intermediate with lithium aluminum tritide and resolved into its d and l isomers in an overall yield of 7.3% based on tritium.

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