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Electrochemical radioiodination of estradiol
Author(s) -
Moore David H.,
Wolf Walter
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150150
Subject(s) - chemistry , halogenation , electrochemistry , iodine , combinatorial chemistry , estrogen , impurity , reaction conditions , chemical synthesis , radiochemistry , organic chemistry , electrode , in vitro , biochemistry , medicine , catalysis
An electrochemical iodination procedure was used to synthesize 2‐iodoestradiol‐ 125 I and 4‐iodoestradiol‐ 125 I. These agents were prepared in order to be studied as potential tumor‐localizing radiopharmaceuticals that might differentiate estrogen‐responsive from non‐responsive breast tumors. The advantages of the electrochemical iodination procedures, as opposed to other chemical and enzymatic methods of iodination, are the higher percentage of incorporation of iodine, shorter reaction time, selective monoiodination, and a very limited amount of impurities as by‐products of the reaction.