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Synthesis of carbon‐14 and deuterium labeled 3‐nitro‐6‐propoxyimidazo [1, 2‐b]pyridazine — An antiparasitic agent
Author(s) -
Fabio P. F.,
Lanzilotti A. E.,
Lang S. A.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150147
Subject(s) - chemistry , pyridazine , carbon 14 , yield (engineering) , antiparasitic , nitro , deuterium , chemical synthesis , antiparasitic agent , nuclear chemistry , radiochemistry , organic chemistry , medicinal chemistry , stereochemistry , in vitro , alkyl , biochemistry , pharmacology , medicine , physics , materials science , pathology , quantum mechanics , metallurgy
A potent antiparasitic agent 3‐nitro‐6‐propoxyimidazo[1, 2‐b]‐pyridazine ( 3 ) was synthesized, labeled with carbon‐14 in the propoxy side chain, from n‐propanol‐1‐ 14 C and 6‐chloro‐3‐nitroimidazo‐[1, 2‐b]pyridazine ( 2 ). The final product was obtained in 58% radiochemical yield with specific activity of 1.13 mCi/mmole and radiochemical purity of greater than 99%. The deuterium labeled compound ( 4 ) was also synthesized for absorption and metabolism studies.