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Purification of labelled retinoic acid and characterization of a major impurity
Author(s) -
McKenzie R. M.,
McGregor M. L.,
Nelson E. C.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150133
Subject(s) - retinoic acid , chemistry , chromatography , high performance liquid chromatography , thin layer chromatography , impurity , epoxide , biochemistry , organic chemistry , catalysis , gene
All‐ trans ‐[15‐ 14 C]retinoic acid and all‐ trans ‐[10,11‐ 3 H 2 ]retinoic acid were purified by thin‐layer chromatography (TLC) and high performance liquid chromatography (HPLC). A major impurity, present in both 14 C‐and 3 H‐labelled retinoic acid, was isolated, characterized and tentatively identified as an epoxide of retinoic acid.