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Synthesisof p ‐(di‐ n ‐propylsulfamyl)benzoic‐1‐(ring)‐ 14 C acid and p ‐(di‐ n ‐propylsulfamyl) benzoic acid‐ 14 C (probenecid‐ 14 C)
Author(s) -
Ellsworth Robert L.,
Maxim Thomas E.,
Mertel Holly E.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150116
Subject(s) - chemistry , benzoic acid , probenecid , ring (chemistry) , toluene , medicinal chemistry , chloride , organic chemistry , pharmacology , medicine
The synthesis of carboxyl‐ 14 C and 1‐(ring)‐ 14 C p‐(di‐ n ‐propylsulfamyl)benzoic acid from carbon‐ 14 C dioxide and p ‐toluene‐1‐(ring)‐ 14 C‐sulfonyl chloride, respectively, is described. p ‐Aminobenzoic‐carboxyl‐ 14 C acid was prepared by an improved method from carbon‐ 14 C dioxide.