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An improved synthesis of N‐acetoxy‐N‐acetyl‐2‐aminofluorene‐9‐ 14 C using an extractive acylation technique
Author(s) -
Thissen M. R.,
Duncan W. P.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150109
Subject(s) - chemistry , acetic anhydride , acylation , acetylation , yield (engineering) , salt (chemistry) , specific activity , ammonium , nuclear chemistry , organic chemistry , chromatography , biochemistry , enzyme , materials science , metallurgy , gene , catalysis
A rapid, high yield (90–100%) method for the preparation of N‐acetoxy‐N‐acetyl‐2‐aminofluorene‐9‐ 14 C (N‐AcO‐AAF‐9‐ 14 C) from N‐hydroxy‐N‐acetyl‐2‐aminofluorene‐9‐ 14 C (N‐OH‐AAF‐9‐ 14 C) is described. The procedure consists of the in situ formation of a quaternary ammonium salt of N‐OH‐AAF‐9‐ 14 C in a two‐phase system and subsequent acetylation of this salt with acetic anhydride. The specific activity of the product was 40.6 mCi/mmole.