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Synthesis of [2‐ 14 C(U)tyrosine]arginine vasotocin with high specific radio and biological activities
Author(s) -
Stahl Glenn L.,
Walter Roderich
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140612
Subject(s) - chemistry , tyrosine , yield (engineering) , peptide synthesis , vasotocin , arginine , specific activity , hormone , peptide , biochemistry , medicine , endocrinology , amino acid , neuropeptide , receptor , enzyme , biology , materials science , metallurgy
The synthesis of [2‐ 14 C(U)tyrosine]arginine vasotocin at a specific activity of 102 mCi/mMole was performed using the solid‐phase approach of Merrifield for peptide synthesis. Following purification by gel filtrations the labeled hormone was recovered at an average yield of 40% with an avian vasodepressor activity of 408 ± 24 U/mg.