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Synthesis of carbon‐14 and tritium labeled N,N′‐(2‐chloro‐5‐cyano‐1,3‐phenylene)dioxamic acid di‐tham salt
Author(s) -
Hsi Richard S. P.,
Johnson Tommy D.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140610
Subject(s) - chemistry , phenylene , tritium , salt (chemistry) , medicinal chemistry , oxalyl chloride , hydrolysis , chloride , carbon 14 , tris , carbon fibers , organic chemistry , nuclear chemistry , polymer , biochemistry , physics , materials science , quantum mechanics , composite number , nuclear physics , composite material
Acetylation of tritium and carbon‐14 labeled 4‐chloro‐3,5‐diaminobenzonitrile (Ia and Ib) with ethyl oxalyl chloride afforded diethyl N,N′‐(2‐chloro‐5‐cyano‐1,3‐phenylene)dioxamate (IIa and IIb). The diester II was hydrolyzed to give N,N′‐(2‐chloro‐5‐cyano‐1,3‐phenylene)dioxamic acid, which was isolated as the tris ‐hydroxymethylaminomethane (THAM) salt III.