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High specific activity tritium labelled O‐benzoyl ecgonine
Author(s) -
Muccino Richard R.,
Serico Lucia
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140605
Subject(s) - chemistry , hydrogenolysis , tritium , radioimmunoassay , substrate (aquarium) , specific activity , catalysis , radiochemistry , enzyme , organic chemistry , biochemistry , physics , oceanography , nuclear physics , geology
Through the use of an O‐(o‐iodobenzoyl) ecgonine derivative ( 3 ), tritium labelled O‐benzoyl ecgonine has been prepared, by catalytic hydrogenolysis, in sufficiently high specific activity for use in radioimmunoassay studies for cocaine metabolites. The ease of converting O‐benzoyl ecgonine to cocaine also makes this labelled substrate potentially useful in metabolism studies of the latter.