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Unnatural nucleosides and nucleotides. III. Preparation of 2‐ 14 C and 4‐ 14 C labelled 5‐alkyluracils and 5‐alkyl‐2′‐deoxyuridines
Author(s) -
Szabolcs A.,
Kruppa G.,
Sági J.,
Ötvös L.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140509
Subject(s) - chemistry , thiourea , alkyl , yield (engineering) , isopropyl , anomer , condensation , nucleotide , carbonic acid , medicinal chemistry , organic chemistry , biochemistry , materials science , physics , gene , metallurgy , thermodynamics
2‐ 14 C Labelled 5‐alkyluracils were prepared by condensation of the diethylacetals of α‐formyl‐carbonic acid esters with 14 C‐thiourea. Compounds labelled at 4‐C were synthesized by condensation of the labelled carboxylic acid derivatives with thiourea. β‐Anomers of 5‐alkyl‐2′‐deoxyuridines were obtained in a fairly good radiochemical yield. Alkyl substituents ranged from methyl to tetradecyl, isopropyl and tertbutyl.