Premium
Synthesis of β‐alanyl‐arginyl‐glycyl‐phenylalanyl‐phenyl‐alanyl‐typosine amide labelled with tritium or carbon‐14
Author(s) -
Hayashi Nobuyoshi,
Kawakami Takeo,
Shinozaki Kazuo,
Wakimasu Mitsuhiro,
Fujino Masahiko
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140407
Subject(s) - chemistry , tritium , amide , residue (chemistry) , tyrosine , yield (engineering) , phenylalanine , arginine , stereochemistry , carbon 14 , radiochemistry , organic chemistry , amino acid , biochemistry , physics , materials science , nuclear physics , metallurgy , quantum mechanics
Abstract The synthesis of β‐Ala‐Arg‐Gly‐Phe‐Phe‐Tyr‐NH 2 labelled with tritium on the tyrosine residue or with carbon‐14 on the arginine residue is described. The tritium labelled compound VII was prepared in 49% radiochemical yield from L‐[3, 5‐ 3 H] tyrosine and benzyloxycarbonyl‐β‐alanyl‐nitro‐arginyl‐glycyl‐phenylalanyl‐phenylalanine. The carbon‐14 labelled compound XVI was synthesized in 17% radiochemical yield from L‐[U‐ 14 C]arginine and glycyl‐phenylalanyl‐phenylalanyl‐tyrosine amide.