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Synthesis of [ 14 C]labelled pyrano[3,4‐b]‐and thiopyrano[3,4‐b]indoles, and indeno[2,1‐c]pyran derivatives
Author(s) -
Ferdinandi E. S.,
Hicks D. R.,
Verbestel W.,
Raman P.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140315
Subject(s) - chemistry , indene , pyran , ring (chemistry) , nucleus , indole test , derivative (finance) , stereochemistry , medicinal chemistry , organic chemistry , financial economics , economics , biology , microbiology and biotechnology
The synthesis of four structurally similar [ 14 C]labelled compounds having a novel heterocylic ring system is described. Three compounds with a tetrahydropyrano (or thiopyrano) indole nucleus were prepared from suitably substituted [ 14 C]tryptophols and were labelled in the pyrano or thiopyrano ring. The preparation of the [ 14 C]tryptophol intermediates from the appropriate gramine is described. The synthesis of the fourth compound, a tetrahydroindenopyran derivative labelled in the indene nucleus, involved a novel preparation of [ 14 C]indene.