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Syntheses with stable isotopes: Benzidine‐ 15 N 2
Author(s) -
Whaley Thomas W.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140213
Subject(s) - benzidine , chemistry , yield (engineering) , amide , sulfate , ammonium , isotope , ammonium chloride , ammonium sulfate , chloride , medicinal chemistry , radiochemistry , nuclear chemistry , inorganic chemistry , organic chemistry , materials science , metallurgy , physics , quantum mechanics
Benzidine‐ 15 N 2 was prepared from 4,4′‐biphenyldicarboxamide‐ 15 N 2 by the Hofmann amide degradation. The diamide, in turn, was obtained from 4,4′‐biphenyldicarbonyl chloride and ammonium‐ 15 N sulfate. An overall yield of 30–35% was obtained for the two steps. An attempted synthesis of N‐hydroxybenzidine is also described.