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Labelled compounds of potential biological interest. V. Preparation of some hypolipidemic agents labelled with tritium
Author(s) -
Gosztonyi Tamas,
Bondesson Göran,
Domeij Karl Erik,
Stjernstroum Nils E.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140211
Subject(s) - chemistry , tritium , clofibrate , moiety , derivative (finance) , carboxylic acid , phenols , radiochemistry , organic chemistry , combinatorial chemistry , biochemistry , physics , nuclear physics , financial economics , economics
Two hypolipidemic aryloxyacetic acid derivatives and one aryloxy‐methylmalonic acid derivative were labelled with tritium in the aryloxy moiety. The corresponding phenols were first labelled by the Yavorsky method and then transformed to the desired products by synthetic reaction steps. For comparative pharmacokinetic and metabolic studies the carboxylic acid corresponding to clofibrate was also labelled by the same procedure.