Premium
Acetylation with acetic‐1– 13 ‐C pivalic anhydride
Author(s) -
Horton Walter J.,
Adams Steven P.,
Niermeyer Mary W.
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130420
Subject(s) - acetic anhydride , chemistry , yield (engineering) , pummerer rearrangement , benzaldehyde , pivalic acid , acetanilide , organic chemistry , acetylation , acetal , catalysis , biochemistry , materials science , metallurgy , gene
In situ formation of acetic‐1– 13 ‐C pivalic anhydride constitutes a convenient and economical means of preparing C‐13 containing acetanilides in excellent yield. Similarly, in situ formation of pivalic anhydride yields pivanilides. An elegant synthesis of p‐acetylaminobenzaldehyde from p‐nitro‐benzaldehyde via the acetal is described.