Premium
Synthesis of deuterium‐labelled drugs, of abuse for use as internal standards in, quantification by selected ion monitoring. II. Deuterium‐labelled benzodiazepines: Chlordiazepoxide, demethyldiazepam, diazepam, and oxazepam
Author(s) -
Fentiman Allison F.,
Foltz Rodger L.
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130417
Subject(s) - oxazepam , chemistry , chlordiazepoxide , deuterium , diazepam , chromatography , radiochemistry , benzodiazepine , pharmacology , biochemistry , medicine , physics , receptor , quantum mechanics
Four deuterium‐labelled benzodiazepines were prepared for use as internal standards in the quantification of chlordiazepoxide, demethyldiazepam, diazepam, and oxazepam at low levels in body fluids by selected ion monitoring. The method described provides a way to introduce cleanly and in high isotopic purity five deuterium atoms into each drug.