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The synthesis of 6‐deoxy‐6‐ 18 F‐α‐D‐galactopyranose (XXII)
Author(s) -
Christman David R.,
Orhanovic Zlata,
Shreeve Walton W.,
Wolf Alfred P.
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130413
Subject(s) - chemistry , yield (engineering) , derivative (finance) , ammonium , fluoride , product (mathematics) , specific activity , medicinal chemistry , stereochemistry , organic chemistry , inorganic chemistry , geometry , materials science , mathematics , economics , financial economics , metallurgy , enzyme
The synthesis of 6‐deoxy‐6– 18 F‐α‐D‐galactopyranose from the 6‐tosyl‐1,2:3,4‐di‐O‐isopropylidene derivative, using tetraethyl‐ammonium fluoride‐ 18 F is described. The synthesis requires 4–4 1/2 hours for completion. The radiochemical yield (activity in compound/starting activity. corrected for decay) is about 15%. Thus 3–4% of the starting 18 F – activity is present at the time of delivery, in approximately 0.2 mg of product.