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The preparation of ( 14 C) and [ 3 H] labelled benzene oxide
Author(s) -
Platt Karl L.,
Oesch Franz
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130403
Subject(s) - benzene , chemistry , oxide , halogenation , decomposition , medicinal chemistry , trimethylsilyl , organic chemistry , nuclear chemistry
Benzene oxide ‐[U‐ 14 C] was prepared from benzene ‐(U‐ 14 C) by modifications of methods described for the inactive compound. Benzene oxide‐[3.6– 3 H] was prepared by decomposition of 3.6‐bis‐trimethylsilyl‐1,4‐cyclohexadiene with tritiated water. bromination of the 1,4‐cyclohexadiene‐[3,6‐ 3 H] so obtained. epoxidation and dehydrobromination. With the latter method benzene oxide‐[3,6– 3 H] can be prepared at a much lower cost and higher specific activity than benzene oxide‐[U‐ 14 C].