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Synthesis of 3‐(hydroxymethyl‐ 14 C)‐8‐methoxychromone‐2 14 C and 3‐hydroxymethyl–8‐methoxychromone‐4‐ 14 C
Author(s) -
Merrill E. J.,
Lewis A. D.
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130314
Subject(s) - hydroxymethyl , chemistry , formaldehyde , radiochemistry , stereochemistry , nuclear chemistry , organic chemistry
A simple route to 3‐(hydroxymethyl‐ 14 C)‐8‐methoxychromone‐2‐ 14 using formaldehyde‐ 14 C is described. However, this material was considered to be unacceptable for most biological studies because about 16% of the radioactivity was expired as 14 CO 2 in the mouse. The synthesis of 3‐methoxysalicylic (carboxyl‐ 14 C) acid is described which was converted in several steps to 3‐hydroxymethyl‐8‐methoxychromone‐4‐ 14 C. Only 0.03% of the radioactivity in this compound was expired as 14 CO 2 .