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Synthesis of 14 C‐labelled compounds. II. Synthesis of 14 C‐methylacetoxy methylnitrosamine
Author(s) -
Braun Horst,
Wiessler Manfred
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130313
Subject(s) - chemistry , methylamine , formaldehyde , hydrochloride , yield (engineering) , silica gel , aqueous solution , distillation , column chromatography , nuclear chemistry , chromatography , organic chemistry , materials science , metallurgy
1,3,5– 14 C‐trimethylhexahydro‐1,3,5‐triazine was prepared by condensing 14 C‐methylamine‐hydrochloride and formaldehyde in a concentrated aqueous solution. The so formed triazine reacts with Nitrosylchloride at 0°C to 14 C‐methylchlorarethylnitrosamine which was not isolated and reacted further with silver acetate. After column chromatography on Silica gel and distillation 14 C‐methylacetoxymethylnitrosamine was obtained in a 24.1% yield based on 14 C‐methylamine‐hydrochloride.