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Preparation of 3,3′‐dichlorobenzidine‐(phenyl‐U‐ 14 C) dihydrochloride
Author(s) -
Duncan W. P.,
Wiley J. C.,
Perry W. C.
Publication year - 1977
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580130302
Subject(s) - chemistry , benzidine , nitrobenzene , acetylation , yield (engineering) , hydrolysis , specific activity , medicinal chemistry , nuclear chemistry , organic chemistry , radiochemistry , enzyme , biochemistry , catalysis , materials science , metallurgy , gene
Abstract A novel five‐step synthesis of 3,3′‐ dichlorobenzidine‐(phenyl‐U 14 C) dihydrochloride is described. The method consists of the preparation of benzidine‐(phenyl‐U‐ 14 C) followed by acetylation, chlorination with N‐chlorosuccinimide (NCS), and hydrolysis. The specific activity of the product was 31.2 mCi/mmole and the overall radiochemical yield was 20% [based on nitrobenzene‐(phenyl‐U‐ 14 C)].