Premium
Labeled metabolites of polycyclic aromatic hydrocarbons. VI. Trans ‐7,8‐dihydrobenzo[ a ]pyrene‐7,8,diol‐G‐ 3 H and (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[ a ]pyrene‐G‐ 3 H
Author(s) -
McCaustland Daniel J.,
Fischer Daniel L.,
Duncan W. P.,
Ogilvie Edward J.,
Engel James F.
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120416
Subject(s) - chemistry , pyrene , diol , epoxy , stereochemistry , organic chemistry , medicinal chemistry
The syntheses of trans ‐7,8‐dihydrobenzo[ a ]pyrene‐7,8‐diol‐G‐ 3 H (V) and (±)‐7α, 8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[ a ]pyrene‐G‐ 3 H (VI) are described. The specific activities of V and VI were 158 mCi/mmole and 220 mCi/mmole, respectively. The key intermediate, trans ‐7,8,9,10‐tetrahydrobenzo[ a ]pyrene‐7,8‐diol‐G‐ 3 H dibenzoate (III), was prepared by catalytic dehalogenation with tritium gas.