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A high yield synthesis of 13 C‐ and 14 C‐labeled diethyl carbonate
Author(s) -
Porter William R.,
Spitznagle Larry A.,
Trager William F.
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120415
Subject(s) - chemistry , carbonate , yield (engineering) , diethyl carbonate , iodide , inorganic chemistry , solvent , silver nitrate , dimethylformamide , barium carbonate , aqueous solution , nuclear chemistry , catalysis , organic chemistry , ethylene carbonate , raw material , electrode , materials science , electrolyte , metallurgy
Labeled silver carbonate was prepared from barium carbonate‐ 13 C or ‐ 14 C and aqueous silver nitrate in 95 to 100% yield. Diethyl carbonate‐ 13 C or ‐ 14 C was generated in 60 to 85% overall yield by treatment of labeled silver carbonate with ethyl iodide and tetraethylammonium iodide in dimethylformamide. The effects of alterations in reaction time, metal ion, solvent and catalyst were investigated.