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Synthesis of 2,4‐diamino‐6‐piperidinylpvrimidine‐3‐oxide‐3′,4′,;5′‐ 3 h(n) tritiated minoxidil
Author(s) -
Gilbertson Terry J.
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120317
Subject(s) - minoxidil , chemistry , piperidine , oxide , pyrimidine , high performance liquid chromatography , radioimmunoassay , chromatography , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , medicine
Minoxidil‐3′,4′,;5′‐ 3 H(N), 25.6 Ci/mM. has been synthesized by the reaction of piperidine‐3,4,5‐ 3 H(N) with 2,4‐diamino‐6‐chloro‐pyrimidine‐3‐oxide. Purification was by paper chromatography. Minoxidil prepared in this way was shown to be suitable for radioimmunoassay and was stable for six months stored in MeOH at 4° C.