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Labeled metabolites of polycyclic aromatic hydrocarbons. V. trans ‐7,8‐dihydrobenzo[ a ]pyrene‐7,8‐diol‐7‐ 14 C and (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[ a ]pyrene‐7‐ 14 C
Author(s) -
McCaustland Daniel J.,
Duncan W. P.,
Engel James F.
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120314
Subject(s) - pyrene , chemistry , diol , epoxy , stereochemistry , organic chemistry , epoxide , medicinal chemistry , catalysis
trans ‐7,8‐Dihydrobenzo[ a ]pyrene‐7,8‐diol‐7‐ 14 C (VI) and (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[ a ]‐pyrene‐7‐ 14 C (VII) were prepared at a specific activity of 53.9 mCi/mmole by a multi‐step synthetic sequence using K 14 CN as the labeled precursor. The overall radiochemical yields for (VI) and (VII) were 18 and 7%, respectively.