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Synthesis of carbon‐13 labelled 6‐substituted benzo ( a ) pyrenes
Author(s) -
Royer Robert E.,
Daub Guido H.,
Jagt David L. Vander
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120306
Subject(s) - chemistry , sodium formate , pyrene , formate , derivative (finance) , formylation , medicinal chemistry , isopropyl , hydrochloride , hydrolysis , benzo(a)pyrene , organic chemistry , financial economics , economics , catalysis
Sodium formate‐ 13 C, prepared by hydrolysis of isopropyl formate, was allowed to react with N‐methylaniline hydrochloride to prepare the formylating agent N‐methylformanilide‐1‐ 13 C. Formylation of benzo( a )pyrene with N‐methylformanilide‐1‐ 13 C gave the 6‐ 13 CHO derivative which was reduced to 6‐ 13 CH 3 and 6‐ 13 CH 2 OH benzo( a )pyrenes. 6‐ 13 CH 2 C1 benzo( a )pyrene was prepared from the 6‐ 13 CH 2 OH derivative.