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Carbon‐14 ring labelling of some methylxanthines of pharmacological importance
Author(s) -
Ayrey G.,
Yeomans M. A.
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120302
Subject(s) - chemistry , xanthine , theobromine , theophylline , uracil , caffeine , labelling , stereochemistry , alkylation , organic chemistry , biochemistry , dna , catalysis , pharmacology , enzyme , medicine , endocrinology
Preparative, separative and analytical methods are described for the following labelled compounds: 4‐amino[5‐ 14 C] formamidouracil (II), 1,3‐dimethyl‐4‐amino[5‐ 14 C]formamidouracil (III), 1,3‐dimethyl[S‐ 14 c]xanthine ([8‐ 14 C]theophylline) (IV), 1,3,7‐trimethyl [8‐ 14 C]xanthine ([8‐ 14 C]caffeine) (V), 4‐amino[2‐ 14 C]uracil (VI),′ 4‐amino‐5‐nitroso[2‐ 14 C]uracil (VII), 4,5‐diamino[2‐ 14 C]uracil (VIII), [2‐ 14 C]xanthine (IX), 3‐methyl[2‐ 14 C]xanthine (X), [2‐ 14 C]theobromine (XI), [2‐ 14 c]theophylline (XII) and [2‐ 14 c]caffeine (XIII).