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The synthesis of 2‐chlorobiphenyl‐1′,2′,3′,4′,5′,6′‐ 14 c 6 , [1]
Author(s) -
Reichardt Paul B.,
Schuttner Scott E.
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120212
Subject(s) - chemistry , yield (engineering) , benzene , biphenyl , salt (chemistry) , ring (chemistry) , medicinal chemistry , reaction conditions , organic chemistry , catalysis , materials science , metallurgy
Modification of the traditional. Gomberg reaction conditions provides a simple, economical. route to 2‐chlorobiphenyl‐1′,2′,3′,4′,5′,6′‐ 14 C 6 (I). The reaction of benzene‐U‐ 14 C 6 with an excess of the diasonium salt from 2 ‐chloroaniline produces 14 C‐labelled I in 10% radiochemical. yield. This method should be applicable to the preparation of any chlorinated biphenyl having one unsubstituted ring .