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Synthesis of 14 C‐labelled 4‐hydroperoxyisophosphamide, an effective antitumor agent
Author(s) -
Nagasaki T.,
Katsuyama Y.,
Minato H.
Publication year - 1976
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580120103
Subject(s) - chemistry , carbon 14 , radiochemistry , yield (engineering) , carbon fibers , molecule , barium carbonate , carbonate , chemical synthesis , absorption (acoustics) , nuclear chemistry , combinatorial chemistry , stereochemistry , organic chemistry , in vitro , biochemistry , raw material , materials science , physics , quantum mechanics , composite number , metallurgy , composite material , acoustics
4‐Hydroperoxyisophosphamide (II), an effective antitumor agent has been labelled with carbon‐14. The carbon‐14 label was incorporated into the C‐6 position of the molecule to give (VII). The overall radiochemical yield was 4.4% based on barium carbonate‐ 14 C. The labelled compound obtained was used for absorption and metabolism studies.