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Syntheses of deuterium‐labelled cholesteryl neoglycolipids
Author(s) -
Lafont Dominique,
Boullanger Paul,
Gambetta Antoine
Publication year - 2012
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1961
Subject(s) - chemistry , triethylene glycol , residue (chemistry) , moiety , deuterium , sugar , organic chemistry , stereochemistry , quantum mechanics , physics
Four deuterium‐labelled neoglycolipids derived from cholesterol were synthesized for embedment into liposomes. Deuterium atoms were either incorporated by CH 2 replacement with a CD 2 group in the triethylene glycol spacer arm between the cholesteryl residue and the sugar moiety (products 2–4 ) or incorporated directly on the acetamido function in the sugar head (compound 5 ).