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Proton exchange reactions in isotope chemistry (I)
Author(s) -
Jian Zhigang,
Ray Tapan,
Wu Amy,
Jones Lawrence
Publication year - 2012
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1959
Subject(s) - chemistry , deuterium , kinetic isotope effect , isotope , radiochemistry , stable isotope ratio , proton , molecule , hydrogen–deuterium exchange , tritium , organic chemistry , hydrogen , nuclear physics , physics
Direct H–D exchange reactions were applied to the preparations of stable isotope‐labeled TKI258 and two TKI258 metabolites. Each compound was made in one single H–D exchange reaction with excellent isotope incorporation. The number of deuterium incorporation and deuterium distribution in the molecules was similar in all three compounds. Stable isotope‐labeled TKI258 was also prepared from d 8 ‐methylpiperazine in a multistep synthesis.