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Highlighting the versatility of the Tracerlab synthesis modules. Part 2: fully automated production of [ 11 C]‐labeled radiopharmaceuticals using a Tracerlab FX C‐Pro
Author(s) -
Shao Xia,
Hoareau Raphaël,
Runkle Adam C.,
Tluczek Louis J. M.,
Hockley Brian G.,
Henderson Bradford D.,
Scott Peter J. H.
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1937
Subject(s) - chemistry , radiosynthesis , radiochemistry , nuclear medicine , medicine , positron emission tomography
The field of radiochemistry is moving toward exclusive use of automated synthesis modules for production of clinical radiopharmaceutical doses. Such a move not only comes with many advantages but also presents radiochemists with the challenge of re‐configuring synthesis modules for production of radiopharmaceuticals that require non‐conventional radiochemistry while maintaining full automation. Herein, we continue our series of articles showcasing the versatility of the Tracerlab FX synthesis modules by presenting straightforward, fully automated methods for preparing a range of carbon‐11 labeled radiopharmaceuticals using a Tracerlab FX C‐Pro . Strategies for production of [ 11 C]acetate, [ 11 C]carfentanil, [ 11 C]choline, [ 11 C]3‐amino‐4‐[2‐[(di(methyl)amino)methyl]phenyl]sulfanylbenzonitrile ([ 11 C]DASB), (+)‐a‐[ 11 C]dihydroterabenazine ([ 11 C]DTBZ), [ 11 C]flumazenil ([ 11 C]FMZ), meta‐hydroxyephedrine ([ 11 C]HED), [ 11 C]methionine, [ 11 C]PBR28, [ 11 C]Pittsburgh Compound B ([ 11 C]PiB), 1‐[ 11 C]methylpiperidin‐4‐yl propionate ([ 11 C]PMP), and [ 11 C]raclopride are presented. Copyright © 2011 John Wiley & Sons, Ltd.