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Synthesis of deuterium‐labeled pregabalin
Author(s) -
Shen Zucheng,
Wu Wenchao,
Wang Wei,
Chen Liqin
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1936
Subject(s) - chemistry , reagent , pregabalin , deuterium , radiochemistry , chemical synthesis , combinatorial chemistry , chromatography , organic chemistry , biochemistry , psychology , physics , quantum mechanics , psychotherapist , in vitro
This paper describes the synthesis of deuterium‐labeled pregabalin. The stable isotopic‐labeled compound was obtained in nine steps starting from the commercially available 4‐[ 2 H 11 ]methylvaleric acid as the stable‐labeled reagent. It is used as an internal standard for analysis and metabolic studies. Pregabalin labeled with 2 H was obtained in nine steps using the commercially available 4‐[ 2 H 11 ]methylvaleric acid as the stable‐labeled reagent. The synthesis prevents deuterium from scrambling and offers the labeled compound with over 99% isotopic enrichment. Copyright © 2011 John Wiley & Sons, Ltd.
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