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[ 18 F]Fluoride recovery via gaseous [ 18 F]HF
Author(s) -
Mathiessen Bente,
Jensen Mikael,
Zhuravlev Fedor
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1931
Subject(s) - chemistry , fluoride , yield (engineering) , distillation , nuclear chemistry , hydrogen fluoride , polyethylene , radiochemistry , inorganic chemistry , outgassing , analytical chemistry (journal) , organic chemistry , metallurgy , materials science
Acidification of target water with H 2 SO 4 in a specially constructed glassy carbon/polyethylene apparatus allowed for recovery of up to 82% of [ 18 F]fluoride as [ 18 F]HF gas. The [ 18 F]HF distillate was found to be acid‐free but moist; when passed through a solution of t BuPh 2 SiOTf, it yielded [ 18 F] t BuPh 2 SiF. The multivariate design of experiment showed that the key to high yield of [ 18 F]HF was the efficient degassing of the reaction mixture.