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Synthesis of carbon‐14 labeled pyraoxystrobin, a novel fungicide
Author(s) -
Liu Xunyue,
Ye Qingfu,
Kan Denglei,
Zhang Zheng,
Ding Xingcheng
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1929
Subject(s) - chemistry , fungicide , yield (engineering) , carbon 14 , radiosynthesis , pyrazole , ring (chemistry) , radiochemistry , chemical synthesis , metabolism , nuclear chemistry , organic chemistry , biochemistry , in vitro , in vivo , botany , materials science , physics , microbiology and biotechnology , quantum mechanics , metallurgy , biology
SYP‐3343, ( E )‐2‐(2‐((3‐(4‐chlorophenyl)‐1‐methyl‐1H‐pyrazole‐5‐yloxy)methyl)) phenyl)‐3‐methoxyacrylate, is a novel fungicide with broad‐spectrum and high activity against fungi. In this paper, radioactive pyraoxystrobin, labeled in the pyrazole ring system was achieved from 14 C labeled 4‐chlorobenzoic acid through substitution, cyclization, and condensation, in an overall chemical and radiochemical yield of 44%. The chemical and radiochemical purity of the title compound was 98.5% and 98.2%, respectively. This labeled SYP‐3343 was used as a radiotracer for metabolism, toxicology, mode of action, and other environmental studies. Copyright © 2011 John Wiley & Sons, Ltd.
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