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Poster Presentation
Author(s) -
Bauwens, Matthias,
de Saint-Hubert, Marijke,
Cleynhens, Jan,
Li, Junjie,
Ni, Yicheng,
Mottaghy, Felix Manuel,
Verbruggen, Alfons
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1926
Subject(s) - presentation (obstetrics) , citation , library science , computer science , medicine , radiology
Methods : A three-step synthetic pathway was followed (scheme 1) and implemented on a GE FastLab system by modifying the original [F]FDG sequence and reagents cassette configuration. The process starts with the [F] F nucleophilic substitution of the trimethylammonium ethylbenzoate compound 1 followed by NaOH hydrolysis performed in the same labeling reactor . After acidification (HCl 0.25M), the resulting [F]Fluorobenzoic acid 3 was trapped and purified on a solid phase extraction cartridge before being coupled to amino-maleimide compound 4 in the next step. This was carried out using diethylcyanophosphonate [3] in acetonitrile at 70°C. Then [F]FBEM could be isolated and purified on a second SPE cartridge.
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