A method for preparing sodium acrylate‐ d  3 , a useful and stable precursor for deuterated acrylic monomers | Zendy

Yang Jun | Zendy; Hong Kunlun | Zendy; Bonnesen Peter V. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A method for preparing sodium acrylate‐ d 3 , a useful and stable precursor for deuterated acrylic monomers

Author(s) -

Yang Jun,

Hong Kunlun,

Bonnesen Peter V.

Publication year - 2011

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1915

Subject(s) - chemistry , acrylate , sodium , yield (engineering) , acrylic acid , monomer , catalysis , deuterium , alkyne , polymer chemistry , nuclear chemistry , organic chemistry , polymer , materials science , metallurgy , physics , quantum mechanics

A convenient and economical method for converting propiolic acid to sodium acrylate‐ d 3 is described. Successive D/H exchange of the alkyne proton of sodium propiolate (prepared from propiolic acid) using D 2 O affords sodium propiolate‐ d having up to 99 at.% D. Sodium propiolate‐ d can be partially reduced to sodium acrylate‐ d 3 with 90% conversion and 89% yield using D 2 and the Lindlar catalyst, with control of reaction parameters to maximize conversion while minimizing over‐reduction. Copyright © 2011 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research