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A simple and efficient synthesis of [ 2 H 10 ]deuterated bromfenvinphos by the Perkow reaction
Author(s) -
Huras Bogumiła,
Konopski Leszek,
Zakrzewski Jerzy
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1885
Subject(s) - chemistry , deuterium , bromide , ethanol , medicinal chemistry , phosphorus trichloride , radiochemistry , organic chemistry , nuclear chemistry , nuclear physics , physics
( E,Z )‐2‐bromo‐1‐(2,4‐dichlorophenyl)vinyl bis[ethyl‐ 2 H 5 ] phosphate ([ 2 H 10 ]bromfenvinphos), a regiospecifically deuterium‐labelled pesticide, was synthesized in two steps starting from [ 2 H 6 ]ethanol, phosphorus trichloride and 2,4‐dichlorophenacylidene bromide, and fully characterized. The deuterated biologically active bromfenvinphos is an important compound for the advancement of environmental degradation testing and some mass spectrometric studies. Copyright © 2011 John Wiley & Sons, Ltd.