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Synthesis of sequentially deuterated 1‐ n ‐Butyl‐3‐methylimidazolium ionic liquids
Author(s) -
Khrizman Alexander,
Cheng Hiu Yan,
Moyna Guillermo
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1884
Subject(s) - chemistry , ionic liquid , deuterium , isotopologue , alkyl , chloride , chemical synthesis , ionic bonding , medicinal chemistry , organic chemistry , ion , catalysis , molecule , nuclear physics , biochemistry , physics , in vitro
Deuterium isotopologues of the ionic liquid (IL) 1– n‐ butyl‐3‐methylimidazolium chloride ([C 4 mim]Cl) sequentially labeled on the C‐1″, C‐1′, C‐2′, C‐3′, and C‐4′ positions of the N ‐alkyl groups were prepared following a strategy that minimizes the number of distinct reactions through the use of analogous synthetic routes. In several cases, good yields after the initial deuterium incorporation reaction were achieved by combining well‐established chemical transformations into efficient single‐step processes. Copyright © 2011 John Wiley & Sons, Ltd.