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Strategy for 14 C‐labeling of a series of bis(heteroaryl)piperazines
Author(s) -
Arjomandi Omid Khalili,
Saemian Nader,
Shirvani Gholamhossein,
Javaheri Mohsen,
Esmailli Kameh
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1880
Subject(s) - chemistry , potassium thiocyanate , moiety , imidazole , hydroxymethyl , stereochemistry , thiocyanate , sequence (biology) , piperazine , combinatorial chemistry , organic chemistry , biochemistry
Four bis(heteroaryl)piperazines labeled with carbon‐14 in the 2‐position of imidazole moiety were prepared as part of a 4‐step (or 5‐step) sequence from 5‐hydroxymethyl‐2‐mercapto‐1‐benzylimida‐zole‐[2‐ 14 C] as a key synthetic intermediate which has been synthesized from potassium [ 14 C]‐thiocyanate. Copyright © 2011 John Wiley & Sons, Ltd.