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Synthetic route to isotopically labelled‐oxamate
Author(s) -
Siwek Agata,
Trotsko Nazar,
Wujec Monika,
Kamiński Rafał,
Paneth Piotr
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1876
Subject(s) - chemistry , labelling , yield (engineering) , carbon 14 , chemical synthesis , combinatorial chemistry , radiochemistry , chromatography , biochemistry , in vitro , materials science , physics , quantum mechanics , metallurgy
Since none of the available methods was suitable for the synthesis of isotopically labelled oxamate, a new procedure has been developed in our laboratory, based on the known procedures, but with substantial modifications. The method is convenient and gives reproducibly 17% yield based on KCN used. The strategy is considered suitable for labelling oxamate with 15 N and 13 C or 14 C when starting with labelled KCN and can be easily modified for the synthesis of 18 O‐carbonyl‐labelled oxamate. Copyright © 2011 John Wiley & Sons, Ltd.