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The efficiency of solvent‐free catalyst systems in the synthesis of tritium‐labelled biologically active compounds
Author(s) -
Shevchenko Valerii P.,
Nagaev Igor Yu.,
Myasoedov Nikolay F.
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1828
Subject(s) - tritium , chemistry , catalysis , solvent , substrate (aquarium) , organic chemistry , combinatorial chemistry , radiochemistry , oceanography , physics , nuclear physics , geology
Modern theories about the processes that take place inside solvent‐free catalyst systems are considered and the various factors that have an effect on the successful introduction of tritium into organic compounds are summarized. Obtaining labelled compounds using solvent‐free catalyst systems, liquid‐phase methods, and isotopic exchange with tritiated water are all regarded as various manifestations of the same set of occurrences in the presence of tritium, a substrate and a catalyst. The use of various isotopic exchange methods has made possible the introduction of tritium into practically any type of biologically active compound. This will enable scientists to carry out more detailed studies of the processes inside living organisms. Copyright © 2010 John Wiley & Sons, Ltd.