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Metal‐catalysed isotopic exchange labelling: 30 years of experience in pharmaceutical R&D
Author(s) -
Allen Paul H.,
Hickey Michael J.,
Kingston Lee P.,
Wilkinson David J.
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1825
Subject(s) - chemistry , labelling , tritium , adme , deuterium , radiochemistry , combinatorial chemistry , biochemistry , nuclear physics , physics , in vitro
Metal‐catalysed exchange has been used extensively in the laboratories of AstraZeneca plc at R&D Charnwood to label a variety of molecules of pharmaceutical interest with the isotopes of deuterium and tritium. Despite early prejudices against the use of tritiated compounds, particularly in ADME studies, the development of directed isotopic exchange techniques has enabled timely and economic support for many pharmaceutical projects. Copyright © 2010 John Wiley & Sons, Ltd.