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Pd‐ and Pt‐catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi‐Aventis perspective
Author(s) -
Atzrodt Jens,
Derdau Volker
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1818
Subject(s) - chemistry , homogeneous , catalysis , perspective (graphical) , organic chemistry , thermodynamics , computer science , physics , artificial intelligence
This review addresses method developments both homogeneous and heterogeneous Pd‐ and Pt‐catalyzed exchange, including catalyst activation principles and recent practical applications together with example procedures. Specific requirements for isotopically labelled internal MS standard preparation are discussed from a Sanofi‐Aventis perspective on recent examples. Copyright © 2010 John Wiley & Sons, Ltd.