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Rhodium‐ and ruthenium‐catalysed hydrogen isotope exchange
Author(s) -
Lockley W. J. S.,
Hesk D.
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1815
Subject(s) - tritium , chemistry , ruthenium , rhodium , deuterium , hydrogen isotope , homogeneous , hydrogen , catalysis , kinetic isotope effect , radiochemistry , isotope , hydrogen–deuterium exchange , inorganic chemistry , organic chemistry , nuclear physics , physics , thermodynamics
Metal‐catalysed hydrogen isotope exchange has been widely used in the preparation of deuterium‐ and tritium‐labelled compounds. This review details the development and utility of homogeneous and heterogeneous rhodium and ruthenium catalysts for the preparation of deuterium‐ and tritium‐labelled compounds by hydrogen isotope exchange methodology. Copyright © 2010 John Wiley & Sons, Ltd.