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The development and use of iridium(I) phosphine systems for ortho‐directed hydrogen‐isotope exchange
Author(s) -
Salter Rhys
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1814
Subject(s) - iridium , phosphine , chemistry , hydrogen isotope , combinatorial chemistry , catalysis , tritium , hydrogen , radiochemistry , organic chemistry , nuclear physics , physics
Abstract Rapid and efficient iridium‐mediated hydrogen‐tritium exchange labeling of pharmaceutical compounds is a key methodology in the life sciences industry. A review of the development and use of iridium(I) phosphine systems for ortho‐directed isotopic exchange is described to provide the reader with a comprehensive introduction to the area and to serve as a starting point for experimental investigators. Examples of useful catalyst systems and their application to different substrates types as well as potential areas for further development are discussed. Copyright © 2010 John Wiley & Sons, Ltd.