The development and use of iridium(I) phosphine systems for ortho‐directed hydrogen‐isotope exchange | Zendy

Salter Rhys | Zendy

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The development and use of iridium(I) phosphine systems for ortho‐directed hydrogen‐isotope exchange

Author(s) -

Salter Rhys

Publication year - 2010

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1814

Subject(s) - iridium , phosphine , chemistry , hydrogen isotope , combinatorial chemistry , catalysis , tritium , hydrogen , radiochemistry , organic chemistry , nuclear physics , physics

Rapid and efficient iridium‐mediated hydrogen‐tritium exchange labeling of pharmaceutical compounds is a key methodology in the life sciences industry. A review of the development and use of iridium(I) phosphine systems for ortho‐directed isotopic exchange is described to provide the reader with a comprehensive introduction to the area and to serve as a starting point for experimental investigators. Examples of useful catalyst systems and their application to different substrates types as well as potential areas for further development are discussed. Copyright © 2010 John Wiley & Sons, Ltd.

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