Premium
Synthesis of I‐131 labelled 4‐iodophenylacetic acid
Author(s) -
Szucs Zoltan,
Sathekge Mike,
MarjanovicPainter Biljana,
Wagener Judith,
Sello Thato,
Wagener Carl,
Zeevaart Jan Rijn
Publication year - 2011
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1812
Subject(s) - chemistry , yield (engineering) , radiochemistry , specific activity , phenylacetate , high performance liquid chromatography , chromatography , organic chemistry , biochemistry , enzyme , materials science , metallurgy
Phenylacetate has been reported to have a potent anti‐proliferative and anti‐differentiating effect in haematological malignancies and in solid tumours at non‐toxic concentrations. This study is a preliminary investigation into the potential of 4‐iodophenylacetic acid radiolabelled by 131 I as a radiopharmaceutical equivalent. The radiolabelling by isotope exchange gave a radiochemical yield of 53±6%, and a radiochemical purity of 97.8±1.2% as qualified by HPLC. The product contained 4% ester by‐product and is suitable for studies in animals. Copyright © 2010 John Wiley & Sons, Ltd.