Synthesis of I‐131 labelled 4‐iodophenylacetic acid | Zendy

Szucs Zoltan | Zendy; Sathekge Mike | Zendy; MarjanovicPainter Biljana | Zendy; Wagener Judith | Zendy; Sello Thato | Zendy; Wagener Carl | Zendy; Zeevaart Jan Rijn | Zendy

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Synthesis of I‐131 labelled 4‐iodophenylacetic acid

Author(s) -

Szucs Zoltan,

Sathekge Mike,

MarjanovicPainter Biljana,

Wagener Judith,

Sello Thato,

Wagener Carl,

Zeevaart Jan Rijn

Publication year - 2011

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1812

Subject(s) - chemistry , yield (engineering) , radiochemistry , specific activity , phenylacetate , high performance liquid chromatography , chromatography , organic chemistry , biochemistry , enzyme , materials science , metallurgy

Phenylacetate has been reported to have a potent anti‐proliferative and anti‐differentiating effect in haematological malignancies and in solid tumours at non‐toxic concentrations. This study is a preliminary investigation into the potential of 4‐iodophenylacetic acid radiolabelled by 131 I as a radiopharmaceutical equivalent. The radiolabelling by isotope exchange gave a radiochemical yield of 53±6%, and a radiochemical purity of 97.8±1.2% as qualified by HPLC. The product contained 4% ester by‐product and is suitable for studies in animals. Copyright © 2010 John Wiley & Sons, Ltd.

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