Synthesis of [ 2 H 4 ]oxymetazoline and [ 14 C]oxymetazoline | Zendy

Brugger Michelle L. | Zendy; Borges Scott | Zendy; Ren Sumei | Zendy; McNamara Paul | Zendy

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Synthesis of [ 2 H 4 ]oxymetazoline and [ 14 C]oxymetazoline

Author(s) -

Brugger Michelle L.,

Borges Scott,

Ren Sumei,

McNamara Paul

Publication year - 2010

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1805

Subject(s) - oxymetazoline , chemistry , yield (engineering) , ethylene diamine , potassium cyanide , benzaldehyde , organic chemistry , cyanide , radiochemistry , nuclear chemistry , biochemistry , catalysis , adrenergic receptor , receptor , materials science , metallurgy

An efficient synthesis of [ 2 H 4 ] and [ 14 C]oxymetazoline has been developed. Both compounds follow the same synthetic route with the introduction of the label occurring at different synthetic steps. The synthesis of [ 2 H 4 ]oxymetazoline from [ 2 H 4 ]ethylene diamine was achieved in one step with a 40% yield. The synthesis of [ 14 C]oxymetazoline from potassium [ 14 C]cyanide was achieved in two steps with an overall radiochemical yield of 67%. Copyright © 2010 John Wiley & Sons, Ltd.

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