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Synthesis of [ 2 H 4 ]oxymetazoline and [ 14 C]oxymetazoline
Author(s) -
Brugger Michelle L.,
Borges Scott,
Ren Sumei,
McNamara Paul
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1805
Subject(s) - oxymetazoline , chemistry , yield (engineering) , ethylene diamine , potassium cyanide , benzaldehyde , organic chemistry , cyanide , radiochemistry , nuclear chemistry , biochemistry , catalysis , adrenergic receptor , receptor , materials science , metallurgy
An efficient synthesis of [ 2 H 4 ] and [ 14 C]oxymetazoline has been developed. Both compounds follow the same synthetic route with the introduction of the label occurring at different synthetic steps. The synthesis of [ 2 H 4 ]oxymetazoline from [ 2 H 4 ]ethylene diamine was achieved in one step with a 40% yield. The synthesis of [ 14 C]oxymetazoline from potassium [ 14 C]cyanide was achieved in two steps with an overall radiochemical yield of 67%. Copyright © 2010 John Wiley & Sons, Ltd.