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A method for the preparation of [ 13 C 6 ]‐labelled 2‐substituted naphthalenes
Author(s) -
Ellames George J.,
Herbert John M.
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1798
Subject(s) - naphthalene , chemistry , bromide , organic chemistry , medicinal chemistry , stereochemistry
A reliable route is described for the preparation of various 2‐substituted derivatives of [1,2,3,4,4a,8a‐ 13 C 6 ]‐naphthalene via the bromide 10. The approach is used to prepare [ naphthalene ‐1,2,3,4,4a,8a‐ 13 C 6 ]‐2‐(2‐bromoethyl)naphthalene (1), a key intermediate in the synthesis of labelled SR57746A, Xaliproden (2). Copyright © 2010 John Wiley & Sons, Ltd.