Palladium‐catalyzed hydroxycarbonylation as the key step in the synthesis of a carbon‐14 labeled Maxi‐K channel blocker | Zendy

Simeone Joseph P. | Zendy; Braun Matthew P. | Zendy; Liu Luping | Zendy; Natarajan Swaminathan R. | Zendy

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Palladium‐catalyzed hydroxycarbonylation as the key step in the synthesis of a carbon‐14 labeled Maxi‐K channel blocker

Author(s) -

Simeone Joseph P.,

Braun Matthew P.,

Liu Luping,

Natarajan Swaminathan R.

Publication year - 2010

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.1755

Subject(s) - chemistry , palladium , catalysis , formate , sodium formate , combinatorial chemistry , carbon fibers , one step , organic chemistry , chemical engineering , composite number , materials science , engineering , composite material

Carbon‐14 labeled sodium formate was utilized for the preparation of a radiolabeled tracer to support the development of a Maxi‐K channel blocker. Key to the process was a palladium‐catalyzed hydroxycarbonylation of a bromoarene for installation of the radiolabel. Copyright © 2010 John Wiley & Sons, Ltd.

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