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Palladium‐catalyzed hydroxycarbonylation as the key step in the synthesis of a carbon‐14 labeled Maxi‐K channel blocker
Author(s) -
Simeone Joseph P.,
Braun Matthew P.,
Liu Luping,
Natarajan Swaminathan R.
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1755
Subject(s) - chemistry , palladium , catalysis , formate , sodium formate , combinatorial chemistry , carbon fibers , one step , organic chemistry , chemical engineering , composite number , materials science , engineering , composite material
Carbon‐14 labeled sodium formate was utilized for the preparation of a radiolabeled tracer to support the development of a Maxi‐K channel blocker. Key to the process was a palladium‐catalyzed hydroxycarbonylation of a bromoarene for installation of the radiolabel. Copyright © 2010 John Wiley & Sons, Ltd.